НОЦ "Фундаментальная и прикладная фотоника. Нанофотоника"

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Самусев Илья Геннадьевич

+7 911 862 04 58

ISamusev@kantiana.ru 

Руководитель направления «Молекулярная спектроскопия. Взаимодействие излучения с веществом. Нанофотоника»

Директор НОЦ «Фундаментальная и прикладная фотоника. Нанофотоника»  БФУ им. И. Канта

 Ученая степень: кандидат физико-математических наук



Научные интересы: Флуоресцентная спектроскопия (в т.ч. с временным разрешением); плазмоника и наноплазмоника; взаимодействие лазерного излучения с веществом; оптические свойства тонких пленок, наночастиц металлов, квантовых точек; спектроскопия комбинационного рассеяния, ИК-спектроскопия.

Деятельность: создание и изучение оптических свойств новых материалов фотоники и нанотехнологий; развитие физических основ молекулярной спектроскопии

Цели:

Проведение научных исследований в области фотопроцессов, связанных с взаимодействием лазерного излучения с веществом, молекулярной спектроскопии и люминесценции, а также наноплазмоники; разработка методик получения наночастиц металлов (серебра, золота, меди и др.) электрохимическими методами и методами фемтосекундной лазерной абляции в жидкости и вакууме с контролем формы и размеров наночастиц  методом фотокорреляционной спектроскопии. 

В состав НОЦ Фундаментальная и прикладная фотоника. Нанофотоника входит две отдельные научно-исследовательские структуры:

 

Лаборатория оптических излучений

Основные направления деятельности НОЦ:

  • Фотофизические процессы переноса плазмонной энергии серебряных наночастиц в комплексах квантовых точек с молекулами органических люминофоров
  • Исследование особенностей фотофизических процессов с участием молекул органолюминофоров и наночастиц в испаряющихся каплях биологических жидкостей
  • Исследование оптических свойств материалов для медицины (комплексы на основе биомолекул, квантовых точек и наночастиц благородных металлов)
  • Исследование штаммов, деактивированных Microbacterium tuberculosis методами флуоресцентной спектроскопии и спектроскопии комбинационного рассеяния с плазмонным усилением
  • Исследование конформационных особенностей сывороточного альбумина человека (САЧ) при сепсисе методами оптической вибрационной спектроскопии и флуоресцентной спектроскопии с временным разрешением
  • Преобразование ИК-энергии лазерного излучения в излучение видимого диапазона в средах, содержащих ионы иттербия и наностержни золота
  • Генерация синглетного кислорода в экстрактах экзотических растений, обладающих люминесцентными свойствами в красной области спектра
  • Взаимодействие оптических и акустических импульсов с веществом
  • Фемтосекундная динамика при короткоимпульсном лазерном возбуждении кластеров наночастиц и молекулярных систем в жидкости и полимерных пленках
  • Синтез наночастиц серебра цитратным и боргидридным методами 

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Научным руководителем школы молекулярной спектроскопии является д.ф.-м.н. профессор Брюханов Валерий Вениаминович. Под его руководством ученики – директор НОЦ Самусев Илья Геннадьевич, Мыслицкая Наталья Александровна , Цибульникова Анна Владимировна – в период с 2005 по 2017 г. защитили свои кандидатские диссертации в МГУ им. М.В. Ломоносова. В 2018 г. еще один сотрудник НОЦ, Зюбин Андрей Юрьевич, защитил кандидатскую диссертацию в СПбГУ под руководством Самусева И.Г. В настоящее время к защите готовится кандидатская диссертация Константиновой Е.И.

В 2013 г. сотрудники НОЦ, под руководством Брюханова В.В., разработали магистерскую программу «Физика оптических процессов и фотоника». В 2017 г. прошел первый выпуск: 6 магистрантов, их них – 5 – с дипломом с отличием, из которых 2 чел. – поступили в аспирантуру по специальности 01.04.05 – «Оптика». В 2017 г. сотрудники НОЦ являются соразработчиками инновационной магистерской программы (на англ. языке) “Functional Nanomaterials for Optics and Photonics”.


Научный коллектив НОЦ

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Брюханов Валерий Вениаминович 

д.ф.-м.н., профессор, ведущий научный сотрудник

Тел.: +7 (906) 230-52-09

e-mail: VBryukhanov@kantiana.rubryukhanov_v.v@mail.ru 

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Зюбин Андрей Юрьевич 

к.ф.-м.н., старший научный сотрудник

Тел.: +7 (906) 212-74-92

e-mail: AZyubin@kantiana.ru; azubin@mail.ru

 


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Цибульникова Анна Владимировна 

к.ф.-м.н., старший научный сотрудник

Тел.: +7 (900) 561-19-76

e-mail: ATsibulnikova@kantiana.rumemorgold@mail.ru 


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Халяпин Вячеслав Анатольевич 

к.ф.-м.н., лаборант-исследователь, Тел.: +7 (906) 216-55-58

e-mail: VKhalyapin@kantiana.ruslavasxi@gmail.com 

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Слежкин Василий Анатольевич 

к.х.н., старший научный сотрудник

Тел.: +7 (911) 458-36-58

e-mail: vslezhkin@mail.ru 



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Мыслицкая Наталья Александровна 

к.ф.-м.н., старший научный сотрудник

Тел.: +7 (921) 106-17-89

e-mail: myslitskaya@gmail.com 



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Константинова Елизавета Ивановна 

младший научный сотрудник

Тел.: +7 (952) 056-37-48

e-mail: EKonstantinova@kantiana.ru; konstantinovaeliz@gmail.com 

 

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Матвеева Карина Игоревна 

аспирант

Тел.: +7 (950) 673-37-00

e-mail: KMatveeva@kantiana.ru; matveeva.k.i@inbox.ru 


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Боркунов Родион Юрьевич 

аспирант

Тел.: +7 (952) 110-43-05

e-mail: RBorkunov@kantiana.ru; rborkunov@mail.ru 


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Царьков Максим Владимирович    

лаборант-исследователь

Тел.: +7 (981) 453-35-47

e-mail: max.offreal@gmail.com


НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ ПРОЕКТЫ НОЦ



















ОСНОВНЫЕ ПУБЛИКАЦИИ НАУЧНОГО КОЛЛЕКТИВА 

Zobkov, M.B., Esiukova, E.E., Zyubin, A.Y., Samusev, I.G.

Microplastic content variation in water column: The observations employing a novel sampling tool in stratified Baltic Sea

(2019) Marine Pollution Bulletin, 138, pp. 193-205.

DOI: 10.1016/j.marpolbul.2018.11.047

КРАТКОЕ ОПИСАНИЕ: A new tool was developed for microplastics (MPs) investigation in the water column. It can collect several cubic meters of water from predefined water layers down to 100 m. The tool was tested in the Baltic Sea during the period of spring thermocline formation. Strong MPs stratification was observed at all of the sampled stations. On coastal stations (~30 m deep), stratification with high fibers content was associated with the proximity of terrestrial sources and estuarine discharges, while on off-shore stations the variability of MPs was related to vertical thermohaline structure. Mean MPs content was the 32.2 (SD 50.4) pcs/m3. Elevated MPs concentrations were observed in subsurface, near-bottom and thermohaline layers compared with intermediate layers. The heterogeneity of MPs distribution suggests that MPs particles can be retained above the density-gradient layers in coastal seas and the World Ocean.

 

Tcibulnikova, A.V., Slezhkin, V.A., Samusev, I.G., Bryukhanov, V.V.

Plasmonic quenching of rhodamine 6G molecules fluorescence in the polyvinyl alcohol films on rough silver surfaces

(2018) Journal of Nanophotonics, 12 (3), статья № 030501.

DOI: 10.1117/1.JNP.12.030501

КРАТКОЕ ОПИСАНИЕ: The optical processes of plasmonic quenching of rhodamine 6G (R6G) molecules fluorescence in polyvinyl alcohol dielectric films formed on rough silver (Ag) surfaces were researched. The depth of penetration of the surface plasmon field into the dielectric film with R6G molecules is calculated. The angular and spectral-kinetic characteristics of dye molecules fluorescence decay on rough Ag surfaces are determined.

 

Samusev, I., Borkunov, R., Tsarkov, M., Konstantinova, E., Antipov, Y., Demin, M., Bryukhanov, V.

Thermal Dynamics of Xanthene Dye in Polymer Matrix Excited by Double Pulse Laser Radiation

(2018) Journal of Physics: Conference Series, 961 (1), статья № 012011.

DOI: 10.1088/1742-6596/961/1/012011

КРАТКОЕ ОПИСАНИЕ: Double-pulse laser excitation of the eosin and silver nanoparticles embedded into polymer media is known to be a method of electronic-vibrational energy deactivation kinetic process information obtaining and polymer thermal dynamics investigation. We have studied the vibrational relaxation processes in dye molecules (eosin) and nanoparticles in polyvinyl alcohol after two time-shifted laser pulses with fast and delayed fluorescence kinetics study. In order to simulate thermal and photophysical processes caused by double photon excitation, we solved heat transfer and energy deactivation differential equations numerically. The simulation allowed us to obtain the value of heat conductivity coefficient of polymer matrix.

 

Zyubin, A.Y., Konstantinova, E.I., Matveeva, K.I., Slezhkin, V.A., Samusev, I.G., Demin, M.V., Bryukhanov, V.V.

Application of silver films with different roughness parameter for septic human serum albumin detection by Surface Enhanced Raman Spectroscopy

(2018) Journal of Physics: Conference Series, 945 (1), статья № 012011.

DOI: 10.1088/1742-6596/945/1/012011

КРАТКОЕ ОПИСАНИЕ: In this paper, the rough silver films parameters investigation, used as media for surface enhancement Raman spectroscopy for health and septic human serum albumin (HSA) study results have been presented. The detection of small concentrations of HSA isolated from blood serum and it main vibrational groups identification has been done.

 

Tcibulnikova, A.V., Samusev, I.G., Slezhkin, V.A., Bryukhanov, V.V.

Effect of plasmonic interaction between rhodamine 6G in polyvinyl alcohol film and rough silver surface: Estimation of absorption energy to plasmon excitation

(2018) Proceedings of SPIE - The International Society for Optical Engineering, 10672, статья № 1067230.

DOI: 10.1117/12.2306779

КРАТКОЕ ОПИСАНИЕ: The optical processes of plasmonic enhancement of rhodamine 6G molecules fluorescence in dielectric films of polyvinyl alcohol deposited on a rough silver surface have been studied. The reflection coefficients of the polarized light components on rough silver surfaces have been determined by means of spectral ellipsometry and spectrophotometry methods. Two kinds of silver surfaces were used: without and with anodizing at current density of 5 mA/cm2 of 0.5 μm layer. The plasmon spectrum appeared to be red-shifted after polyvinyl film deposition onto the silver plate. I was shown that the silver-dielectric interface roughness affects the position of the reflected light spectrum maximum to 360 - 400 nm range due to the dielectric polarizing effect.

 

Konstantinova, E.I., Zyubin, A.U., Slezhkin, V.A., Samusev, I.G., Bryukhanov, V.V.

Raman spectroscopy study of the optical properties of human serum albumin with dye aqueous solution droplet in presence of silver nanoparticles

(2018) Proceedings of SPIE - The International Society for Optical Engineering, 10672, статья № 106722S.

DOI: 10.1117/12.2306595

КРАТКОЕ ОПИСАНИЕ: In this paper by the methods of Raman spectroscopy, a drop of the evaporating liquid of Human Serum Albumin with the Rhodamine 6G dye molecules in the presence of silver nanoparticles obtained by laser femtosecond ablation in water was studied. In the Raman spectra, an increase in the intensity of scattering of dye molecules with silver nanoparticles the addition of protein molecules was recorded. We suppose that the observed effect is associated with the diffusion and thermal processes in the drop arising during laser excitation.

 

Tcibulnikova, A.V., Samusev, I.G., Bryukhanov, V.V., Slezhkin, V.A., Borkunov, R.Y.

Plasmon enhancement of porphyrin molecules fluorescence in the presence of ytterbium nanoparticles

(2018) Proceedings of SPIE - The International Society for Optical Engineering, 10672, статья № 1067231.

DOI: 10.1117/12.2306818

КРАТКОЕ ОПИСАНИЕ: The article explores the influence of plasma energy of ytterbium nanoparticles on the fluorescent and absorption characteristics of the porphyrin molecules (Ethioporphyrin) in methylcellulose films. There has been ascertained the presence of plasmon energy transfer in the porphyrin-cluster system of the ytterbium nanoparticle at the wavelengths of fluorescence registration. The values of the increase in percentage proportion were defined. It was demonstrated that with the clusters concentration increasing the optical density of porphyrin molecules and fluorescence intensity increases.

 

Bashkatov, A.N., Berezin, K.V., Dvoretskiy, K.N., Chernavina, M.L., Genina, E.A., Genin, V.D., Kochubey, V.I., Lazareva, E.N., Pravdin, A.B., Shvachkina, M.E., Timoshina, P.A., Tuchina, D.K., Yakovlev, D.D., Yakovlev, D.A., Yanina, I.Y., Zhernovaya, O.S., Tuchin, V.V.

Measurement of tissue optical properties in the context of tissue optical clearing

(2018) Journal of Biomedical Optics, 23 (9), статья № 091416.

DOI: 10.1117/1.JBO.23.9.091416

КРАТКОЕ ОПИСАНИЕ: Nowadays, dynamically developing optical (photonic) technologies play an ever-increasing role in medicine. Their adequate and effective implementation in diagnostics, surgery, and therapy needs reliable data on optical properties of human tissues, including skin. This paper presents an overview of recent results on the measurements and control of tissue optical properties. The issues reported comprise a brief review of optical properties of biological tissues and efficacy of optical clearing (OC) method in application to monitoring of diabetic complications and visualization of blood vessels and microcirculation using a number of optical imaging technologies, including spectroscopic, optical coherence tomography, and polarization- And speckle-based ones. Molecular modeling of immersion OC of skin and specific technique of OC of adipose tissue by its heating and photodynamic treatment are also discussed.

 

Yanina, I.Y.U., Lazareva, E.N., Tuchin, V.V.

Refractive index of adipose tissue and lipid droplet measured in wide spectral and temperature ranges

(2018) Applied Optics, 57 (17), pp. 4839-4848.

КРАТКОЕ ОПИСАНИЕ: This study presents refractive index measurements of human and porcine adipose tissues and lipid droplet content in the visible and near-infrared. The coefficients of the Sellmeier formula were calculated for approximation of tissue dispersion. For the first time, to the best of our knowledge, the phase transition temperatures and temperature increments dn∕dT of adipose tissue were quantified for a wide wavelength range from 480 to 1550 nm and from room temperature up to 50°C. For human abdominal adipose tissue, the refractive index increment averaged across all wavelengths is dn∕dT −3.54 0.15 × 10−4°C−1, for porcine tissue dn∕dT −7.920.74 × 10−4°C−1, and for porcine lipid droplet dn∕dT −6.010.29 × 10−4°C−1. Data available in literature for refractive indices of adipose tissues measured by different techniques are summarized and compared with the received data.

 

Lazareva, E.N., Tuchin, V.V.

Measurement of refractive index of hemoglobin in the visible/NIR spectral range

(2018) Journal of Biomedical Optics, 23 (3), статья № 035004.

DOI: 10.1117/1.JBO.23.3.035004

КРАТКОЕ ОПИСАНИЕ: This study is focused on the measurements of the refractive index of hemoglobin solutions in the visible/near-infrared (NIR) spectral range at room temperature for characteristic laser wavelengths: 480, 486, 546, 589, 644, 656, 680, 930, 1100, 1300, and 1550 nm. Measurements were performed using the multiwavelength Abbe refractometer. Aqua hemoglobin solutions of different concentrations obtained from human whole blood were investigated. The specific increment of refractive index on hemoglobin concentration and the Sellmeier coefficients were calculated.

 

Lazareva, E.N., Zyubin, A.Y., Samusev, I.G., Slezhkin, V.A., Kochubey, V.I., Tuchin, V.V.

Refraction, fluorescence, and Raman spectroscopy of normal and glycated hemoglobin

(2018) Proceedings of SPIE - The International Society for Optical Engineering, 10685, статья № 1068540.

DOI: 10.1117/12.2307102

КРАТКОЕ ОПИСАНИЕ: In this study, the optical properties of glycated (HbA1c) and non-glycated (Hb) hemoglobin are compared using refractometry, fluorescence and Raman spectroscopy. The fluorescence measured at an excitation wavelength of 270 nm indicates differences in the molecular structure of hemoglobins. Analysis of the spectral shift of Raman spectra also showed variations indicating differences in their molecular structure. The refractive index measured in the visible and near IR regions for different temperatures allowed for quantification of mean values of temperature increment, which are quite different as dn/dT= -(1.03 ± 0.05)×10-4°C-1 for Hb and - (1.37 ± 0.07)×10-4°C-1for HbA1c.The data obtained in the work can serve as a basis for further study of the optical properties of glycated hemoglobin and other glycated proteins.

 

Bugay, A.N., Khalyapin, V.A.

Evolution of super-Gaussian pulses in a nonlinear optical fiber

(2018) Laser Physics, 28 (4), статья № 045403.

DOI: 10.1088/1555-6611/aaa5d7

КРАТКОЕ ОПИСАНИЕ: An analytic and numerical study is carried out of the dynamics of parameters of a super-Gaussian pulse whose spectrum can fit both in the region of normal and anomalous dispersion of the group velocity. An analytical solution is found for the parameter characterizing the evolution of the degree of the super-Gaussian momentum. The loss of profile rectangularity is shown to be much faster than the pulse dispersion broadening, and corresponding characteristic length is determined by explicit formula.

 

Zyubin, A., Konstantinova, E., Samusev, I., Bryukhanov, V.

Fluorescent study of human health and septic albumin doped with Ag nanoparticles

(2017) Progress in Electromagnetics Research Symposium, 2017-November, pp. 103-105.

DOI: 10.1109/PIERS-FALL.2017.8293118

КРАТКОЕ ОПИСАНИЕ: Finding new, non-invasive optical methods for protein investigation is an actual task for physicists. Fluorescent spectroscopy acts as a perspective instrument for the bimolecular investigation and it conformational changes study. Understanding the structural changes of the human serum albumin (HSA), at the molecular level, during pathology, is a key for development of new methods of in-vitro diagnostics. In this paper we perform results of conformational analysis carried out by fluorescent spectroscopy, Fluorescence spectra were obtained by Fluorolog-3 scientific unit. Fluorescent spectral changes of tryptophan residues group were analyzed. Usage of Ag nanoparticles, as enhancement media for biomolecules detection was demonstrated. Application of luminescent spectroscopy for conformational analysis of HSA was shown.

 

Samusev, I., Tsibulnikova, A., Zyubin, A., Borkunov, R., Alekseenko, I., Bryukhanov, V.

Ytterbium nanoparticles fabricated by fs-laser ablation raman spectroscopy study

(2017) Progress in Electromagnetics Research Symposium, 2017-November, pp. 106-108.

DOI: 10.1109/PIERS-FALL.2017.8293119

КРАТКОЕ ОПИСАНИЕ: Ytterbium nanoparticles have been fabricated by means of metal film fs-laser ablation in heptane with surface active reagent (SAR). The micellar solution of nanoparticles in the ablation process acquired a brown color. Ytterbium nanoparticles laser ablation was carried out on Theta 25/30 AVESTA (Russia) femtosecond pulsed laser unit with energy of 5 and 10 μJ. Ytterbium nanoparticles film was prepared by equal volume surface active reagent 5-times pouring on glass surface. Metallic ytterbium thin films were also fabricated from Yb powder by means 10 ton pressure. The samples were studied by Raman spectroscopy method with laser excitation wavelength of 473 nm.

 

Nosan, M.M., Omelyanchik, A.S., Samusev, I.G., Myslitskaya, N.M., Borkunov, R.Y., Lyatun, I.I., Rodionova, V.V., Bryukhanov, V.V.

Magnetic properties of nanoparticles prepared from α-Fe target by laser ablation in liquids

(2017) Progress in Electromagnetics Research Symposium, 2017-November, pp. 109-113.

DOI: 10.1109/PIERS-FALL.2017.8293120

КРАТКОЕ ОПИСАНИЕ: This study aims to examine nanoparticles fabrication by nanosecond and femtosecond laser ablation of iron target in different liquids. Effect of liquid environment, pulse width and power of beam on the magnetic properties of produced nanoparticles have been studied experimentally by measuring the hysteresis loops at room temperature. It was found that saturation magnetization was increased by an order of magnitude for samples prepared by femtosecond laser. Significant change in coercive force and magnetization for samples prepared with different power of femtosecond laser beam were observed.

 

Konstantinova, E.I., Tikhomirova, N.S., Samusev, I.G., Slezhkin, V.A., Bryukhanov, V.V.

Donor–acceptor interactions between resonance-excited silver nanoparticles and halide ions in water solutions

(2017) Russian Journal of Physical Chemistry A, 91 (10), pp. 2012-2017.

DOI: 10.1134/S003602441710020X

КРАТКОЕ ОПИСАНИЕ: Donor–acceptor interactions between silver nanoparticles (NPs), resonance-excited by optical quanta of light, and halide ions are studied in aqueous solutions. It is shown that deactivation of the plasmon excitation of Ag NP proceeds according to the exchange mechanism of electron transfer. Plasmon excitation quenching constants are determined and a correlation between quenching and the donor properties of halide ions is found. The efficiency of electrostatic interaction between resonantly-excited Ag NPs and halide ions is studied, and their dipole moment is determined.

Krasnikov, I., Seteikin, A., Kniggendorf, A.-K., Meinhardt-Wollweber, M., Roth, B.

Simulation of Raman scattering including detector parameters and sampling volume

(2017) Journal of the Optical Society of America A: Optics and Image Science, and Vision, 34 (12), pp. 2138-2144.

DOI: 10.1364/JOSAA.34.002138

КРАТКОЕ ОПИСАНИЕ: Raman spectroscopy can be employed to measure the chemical composition of a sample, which can in turn be used to extract biological information. The aim of this paper is to introduce an efficient simulation technique for Raman spectroscopy in turbid (scattering) media taking into account relevant detector parameters and the sampling volume. We simulate the process of photon motion in turbid media by means of the Monte Carlo (MC) method. The numerical simulation of Raman scattering consists of two stages: calculation of the photon fluence at each point of the medium and subsequent generation of the corresponding amount of Raman photons at each point. The developed model allows simulation of both confocal and optical fiber probe Raman setups. In more detail, the model efficiently simulates Raman signals for different single and multi-layer phantoms and geometries, including focused and collimated (i.e., the fiber-based case) excitation laser beams as well as different values for the numerical aperture and the excitation beam radius. In the future, our results offer the potential to improve the design of Raman systems for in vivo applications in biomedical research.

 

Tikhomirova, N.S., Samusev, I.G., Slezhkin, V.A., Bryukhanov, V.V.

Rhodamine 6G Fluorescence Quenching by an External Heavy Atom and Silver Nanoparticles at the Nanoporous-Silica-Water Boundary

(2017) Journal of Applied Spectroscopy, 84 (3), pp. 376-381.

DOI: 10.1007/s10812-017-0479-2

КРАТКОЕ ОПИСАНИЕ: Spectral and kinetic features of rhodamine 6G fluorescence quenching in a heterogeneous system of macroporous silica (silokhrom, S-80) and water caused by the combined influence of an external heavy atom (KI) and resonance-excited surface plasmons on citrate hydrosol silver nanoparticles. Surface plasmon quenching occurred through donor–acceptor interaction in complexes with iodide and silver nanoparticles. The activation energy of dye fluorescence quenching in the heterogeneous system had a minimum that was associated with hindered diffusion during the formation of silver-nanoparticle clusters.

 

Alexeenko, I.V., Gusev, M.E., Redkorechev, V.I., Zyubin, A.Y., Samusev, I.G.

Digital holographic interferometry for the nanodisplacement measurement

(2017) Progress in Electromagnetics Research Symposium, pp. 610-612.

DOI: 10.1109/PIERS.2017.8261813

КРАТКОЕ ОПИСАНИЕ: The sensitivity of digital holographic interferometry methods for a surface nanodisplacement measurement is represented. The effect of hardware digitalization parameters on the sensitivity of digital holographic measurements is considered. The investigation of surfaceacoustic waves was carried out by digital holographic interferometry technique in order to reconstruct and estimate the amplitude of those waves. The experiment represented that the amplitude of surfaceacoustic waves were about 10 nanometers.

 

Zyubin, A., Alekseenko, I., Samusev, I., Babak, S., Demin, M., Bryukhanov, V.

Laser induced cell death stages investigation by Raman spectroscopy

(2017) Progress in Electromagnetics Research Symposium, pp. 63-65.

DOI: 10.1109/PIERS.2017.8261707

КРАТКОЕ ОПИСАНИЕ: In this paper we perform results of laser induced apoptosis and necrosis stages study in live rats cancer cells. Induction of cell death was carried out at various conditions of laser power and time exposure. Stages of apoptosis were controlled by optical microscopy. During cell death process, Raman spectra of apoptotic and necrotic cells were registered at Centaur U HR science unit equipped with 532 diode laser. We focused on detection signal intensity level and Raman bands position as markers of cell death stages. Both single cancer cells and cells groups were investigated using Raman scattering spectroscopy. Applicability of noninvasive Raman spectroscopy was shown for identification of cell death stages.

 

Tikhomirova, N.S., Samusev, I.G., Slezhkin, V.A., Zyubin, A.Y., Bryukhanov, V.V.

Plasmon Processes of Electronic Energy Transfer to Adsorbed Rhodamine 6G During Clustering of Silver Nanoparticles on the Surface of Macroporous Silica

(2017) Journal of Applied Spectroscopy, 84 (2), pp. 261-267.

DOI: 10.1007/s10812-017-0461-z

КРАТКОЕ ОПИСАНИЕ: Spectral and kinetic features of the optical conversion of electronic energy were studied during dipole–dipole transfer of electronic excitation between silver (Ag) sol nanoparticles (NPs) of small and medium sizes and rhodamine 6G (R6G) molecules on the surface of a macroporous silica (C-80) with an irregular pore structure. It was found that Ag NPs were adsorbed unevenly to the C-80 surface with clusters of differently sized Ag NPs distributed as islets. Threshold gain of the light scattered by surface plasmons was detected at a certain concentration of Ag NPs on the silica. Local plasmon excitations in Ag NP clusters on the silica were evaluated quantitatively.

 

Zyubin, A., Lavrova, A., Manicheva, O., Dogonadze, M., Tsibulnikova, A., Samusev, I.

Methodology of mycobacteria tuberculosis bacteria detection by Raman spectroscopy

(2017) Proceedings of SPIE - The International Society for Optical Engineering, 10456, статья № 104565L.

DOI: 10.1117/12.2282967

КРАТКОЕ ОПИСАНИЕ: We have developed a methodology for the study of deactivated strains of Mycobacterium tuberculosis. Strains of the Beijing species obtained from pulmonary patient secrete (XDR strain) and reference strain (H37Rv) were investigated by Raman spectrometry with He-Ne (632,8 nm) laser excitation source. As a result of the research, the optimal experimental parameters have been obtained to get spectra of mycolic acids, which are part of the cell wall of mycobacteria.

 

Konstantinova, E., Zyubin, A., Moiseeva, E., Matveeva, K., Slezhkin, V., Samusev, I., Bryukhanov, V.

Application of quantum dots CdZnSeS/ZnS luminescence, enhanced by plasmons of silver rough surface for detection of albumin in blood facies of infected person

(2017) Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10592, статья № 105920C.

DOI: 10.1117/12.2299718

КРАТКОЕ ОПИСАНИЕ: The study of the luminescence of CdZnSeS/ZnS quantum dots (QDs) absorbed on the rough surface of a silver film, including the energy transfer between human serum albumin molecules, isolated from the blood plasma of healthy and infected with sepsis patients, was performed by spectral-kinetic methods.

 

Zyubin, A., Konstantinova, E., Slezhkin, V., Matveeva, K., Samusev, I., Bryukhanov, V.

Application of fluorescent and vibration spectroscopy for septic serum human albumin structure deformation during pathology

(2017) Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10592, статья № 1059205.

DOI: 10.1117/12.2295315

КРАТКОЕ ОПИСАНИЕ: In this paper we perform results of conformational analysis of septic human serum albumin (HSA) carried out by Raman spectroscopy (RS), infrared (IR) spectroscopy and fluorescent spectroscopy. The main vibrational groups were identified and analyzed for septic HSA and its health control. Comparison between Raman and IR results were done. Fluorescent spectral changes of Trp-214 group were analyzed. Application of Raman, IR spectroscopy, fluorescent spectroscopy for conformational changes study of HSA during pathology were shown.

 

Tcibulnikova, A.V., Borkunov, R.Y., Bryukhanov, V.V., Slezhkin, V.A., Zyubin, A.Y., Samusev, I.G.

Visible and IR spectroscopy of ablative ytterbium nanoparticles

(2017) Proceedings of SPIE - The International Society for Optical Engineering, 10456, статья № 104564K.

DOI: 10.1117/12.2282558

КРАТКОЕ ОПИСАНИЕ: The presence of plasmon resonance in the region of 375 nm for ytterbium nanoparticles obtained by laser ablation in the stabilizer of AOT in heptane is established in the work. The dimensions of the ytterbium nanoparticles are determined by the dynamic scattering method. Raman spectra and absorption spectra were measured in the IR region. Characteristic vibration frequencies for ytterbium nanoparticles and scattering bands for a pure ytterbium metal surface are determined.

 

Lavrova, A.I., Postnikov, E.B., Zyubin, A.Y., Babak, S.V.

Ordinary differential equations and boolean networks in application to modelling of 6-mercaptopurine metabolism

(2017) Royal Society Open Science, 4 (4).

DOI: 10.1098/rsos.160872

КРАТКОЕ ОПИСАНИЕ: We consider two approaches to modelling the cell metabolism of 6-mercaptopurine, one of the important chemotherapy drugs used for treating acute lymphocytic leukaemia: kinetic ordinary differential equations, and Boolean networks supplied with one controlling node, which takes continual values. We analyse their interplay with respect to taking into account ATP concentration as a key parameter of switching between different pathways. It is shown that the Boolean networks, which allow avoiding the complexity of general kinetic modelling, preserve the possibility of reproducing the principal switching mechanism.

 

Bogaychuk, A., Zyubin, A., Lavrova, A., Kupriyanova, G., Babak, S., Dambieva, M., Demin, M., Borisova, A., Opryshko, N.

Dataset on metabolomics profile of acute leukemia blood obtained by the NMR methods

(2017) Data in Brief, 11, pp. 479-483.

DOI: 10.1016/j.dib.2017.02.035

КРАТКОЕ ОПИСАНИЕ: This article contains NMR (nuclear magnetic resonance) experimental data, obtained by the NMR Varian 400 MHz spectrometer (USA) which can be used for the metabolites identification in human blood. Data include analyzed NMR spectra of plasma proteins extracted from human blood of 24 patients (0–5 years old) with the confirmed acute leukemia diagnosis. Data can provide information about metabolites and their concentration in blood

 

Malashchenko, V., Zyubin, A., Babak, S., Lavrova, A.

ATP concentration as possible marker of liver damage at leukaemia treatment: Confocal microscopy-based experimental study and numerical simulations

(2017) Proceedings of SPIE - The International Society for Optical Engineering, 10337, статья № 103371B.

DOI: 10.1117/12.2267951

КРАТКОЕ ОПИСАНИЕ: We consider the method of confocal microscopy as a convenient instrument for determination of chemical compounds in biological tissues and cells. In particular, we study the dynamics of adenosine triphosphate (ATP) concentration that could be used as a bio-marker of energy metabolism pathologies at the treatment of acute lymphoblastic leukaemia (ALL). On the basis of data obtained by the confocal microscopy, the values of ATP concentration have been calculated for each case. Possible correlations with other characteristics of pathology processes obtained from plasma of leukemia patients show that ATP value could be a prognostic factor of the treatment success. The role of ATP in the drug metabolism switching is also discussed within the context of kinetic modelling of metabolism processes leading to the production of 6-Thioguanosine monophosphate, which is a principal acting agent in chemotherapy.

 

Zyubin, A., Lavrova, A., Demin, M., Pankina, A., Babak, S.

The data obtained during the analysis of clinical blood samples for children acute lymphoblastic leukemia patients with severe side-effects

(2017) Data in Brief, 11, pp. 522-526.

DOI: 10.1016/j.dib.2017.03.016

КРАТКОЕ ОПИСАНИЕ: The present work contains data obtained during the analysis of blood samples obtained from patients (number: 102, age: 0–2 years old) with confirmed acute lymphoblastic leukemia diagnosis. Among these total number, 48 patients who received a chemotherapy including 9 patients with side-effects were chosen. Final data include a table of protein masses (biomarkers of pathological processes at the chemotherapy) obtained by the MALDI-TOF spectroscopy from blood of 9 chosen patients (0–2 years old).

 

Tcibulnikova, A.V., Degterev, I.A., Bryukhanov, V.V., Roberto, M.M., Campos Pereira, F.D., Marin-Morales, M.A., Slezhkin, V.A., Samusev, I.G.

The participation of singlet oxygen in a photocitotoxicity of extract from amazon plant to cancer cells

(2017) Proceedings of SPIE - The International Society for Optical Engineering, 10456, статья № 104563E.

DOI: 10.1117/12.2283317

КРАТКОЕ ОПИСАНИЕ: We have been searching for new photosensitizers (PS) for photodynamic therapy (PDT) of cancer based on extracts from Amazonian plants since 2009. In this paper, we demonstrate that, under certain conditions, the extract from fruits of the Amazonian palm Euterpe oleraceae (popular name Açaí) can serve as a PS for PDT treatment of murine breast cancer cells (4T1 cell line). We have been first to show directly that the photodynamic effect of plant PS is due to singlet oxygen.

 

Bugay, A.N., Khalyapin, V.A.

On the analytical description of self-frequency shift of a pulse propagating in the region of zero group-velocity dispersion

(2017) Optics and Spectroscopy, 123 (2), pp. 183-188.

DOI: 10.1134/S0030400X17080021

КРАТКОЕ ОПИСАНИЕ: An analytical expression describing the frequency shift of nonsoliton pulses in a nonlinear Raman-active medium is obtained by the method of moments. The regime of propagation in which the central frequency of the signal falls into the region of zero group-velocity dispersion is analyzed.

 

Bugay, A.N., Khalyapin, V.A.

Analytic description of Raman-induced frequency shift in the case of non-soliton ultrashort pulses

(2017) Physics Letters, Section A: General, Atomic and Solid State Physics, 381 (4), pp. 399-403.

DOI: 10.1016/j.physleta.2016.11.018

КРАТКОЕ ОПИСАНИЕ: Raman-induced frequency shift of ultrashort pulses have been studied extensively for the soliton propagation regime. Here we derive explicit analytic expressions for the evolution of Raman-induced frequency shift in much less studied case of non-soliton ultrashort pulses. Pulse spectra may belong to any region of group velocity dispersion including zero group dispersion point. The analysis is based on the moment method. Obtained expressions fit well to the numerical solution of the nonlinear wave equation.

 

Konstantinova, E.I., Zyubin, A.U., Slezhkin, V.A., Samusev, I.G., Bryukhanov, V.V.

Plasmon enhancement of Raman scattering and fluorescence for rhodamine 6G molecules in the porous glass and PVA films with nanoparticles of silver citrate hydrosol

(2016) Journal of Physics: Conference Series, 737 (1), статья № 012037.

DOI: 10.1088/1742-6596/737/1/012037

КРАТКОЕ ОПИСАНИЕ: The study of Raman and fluorescence spectra for Rhodamine 6G molecules in a film of polyvinyl alcohol on the modified by silver nanoparticles (NPs) porous glass and without the porous glass has been done. The gain of the scattering intensity and fluorescence emission has been obtained in the presence of silver nanoparticles. The gain order was obtained as ∼1011.

 

Zyubin, A., Lavrova, A., Babak, S., Malaschenko, V., Borisova, A., Opryshko, N.

Childhood lymphoblastic leukemia adverse drug reactions: Study of risk factors and therapy prognosis by optical methods

(2016) Proceedings of SPIE - The International Society for Optical Engineering, 10024, статья № 1002432.

DOI: 10.1117/12.2246024

КРАТКОЕ ОПИСАНИЕ: The treatment of acute lymphoblastic leukemia (ALL) can result in the side-effects such as kidney affection, hepatic failure and tissue hypoxia. We study dynamics of special biochemical marker of these pathologies - adenosine triphosphate, that is well-known substance of energy metabolism. We use methods of confocal microscopy for determining the cellular and mitochondrial concentration of adenosine triphosphate (ATP). Quantitative values of adenosine triphosphate were calculated for each patient and correlation with degree of side-effects had been done. The application of confocal microscopy for studying of side-effects and therapy of lymphoblastic leukemia is discussed.

 

Tikhomirova, N.S., Myslitskaya, N.A., Samusev, I.G., Bryukhanov, V.V.

Plasmon Enhancement of Electronic Energy Transfer Between Quantum Dots on the Surface of Nanoporous Silica

(2016) Journal of Applied Spectroscopy, 82 (6), pp. 961-969.

DOI: 10.1007/s10812-016-0212-6

КРАТКОЕ ОПИСАНИЕ: We use spectral kinetic methods to study electronic energy transfer processes between semiconductor quantum dots on the surface of wide-pore silica in the absence of and in the presence of silver nanoparticles, obtained by laser ablation methods. We have determined the efficiencies of dipole–dipole energy transfer between two-shell (CdSe/CdS/ZnS) and one-shell (CdSe/ZnS) quantum dots on the surface, the luminescence lifetimes and quantum yields, transfer distances and transfer rate constants. We have studied enhancement of photoprocesses in individual quantum dots and in a pair under the influence of resonant localized plasmons of ablative silver nanoparticles.

 

Samusev, I.G., Tikhomirova, N.S., Slezhkin, V.A., Zyubin, A.Y., Bryukhanov, V.V., Tsibulnikova, A.V.

Silver nanoparticles plasmonic effect on eosin and rhodamine 6G luminescence in various media

(2016) Proceedings of SPIE - The International Society for Optical Engineering, 10027, статья № 1002714.

DOI: 10.1117/12.2242407

КРАТКОЕ ОПИСАНИЕ: The plasmonic enhancement and quenching of phosphorescence and fluorescence of the anionic (eosin) and cationic (rhodamine 6G) dyes have been studied in various environments: silver nanoparticles of silver hydrosol citrate in water, in polymer films and on the surface of nanoporous silica in order to determine the kinetic and spectral effects on the dye luminescence. Depending on the silver nanoparticles concentration both the enhancement and quenching of the dyes phosphorescence and fluorescence have been detected. The mechanism of interaction between the excited molecules and silver nanoparticles has been discussed.

 

Letuta, S.N., Pashkevich, S.N., Ishemgulov, A.T., Lantukh, Y.D., Alidzhanov, E.K., Sokabaeva, S.S., Bryukhanov, V.V.

Delayed luminescence of erythrosine in biological tissue and photodynamic therapy dosimetry

(2016) Journal of Photochemistry and Photobiology B: Biology, 163, pp. 232-236.

DOI: 10.1016/j.jphotobiol.2016.08.036

КРАТКОЕ ОПИСАНИЕ: The features of delayed fluorescence (DF) and phosphorescence in erythrosine stained healthy and cancer-diseased mammary gland tissues of BYRB-line mice were investigated in vitro. Thermoactivated delayed fluorescence (TDF), triplet-triplet annihilation (TTA) and originated from singlet-triplet annihilation (STA) delayed fluorescence are investigated as competing channels of radiative relaxation of the triplet states of erythrosine. The dominant role of diffusive-mobile molecular oxygen in deactivation of triplet-excited long-live states of the dye molecules in cells is determined. The previously not described phenomenon of light quenching of DF under pulsed laser irradiation (light quenching of DF, LQDF) in stained tissue was revealed. LQDF is increased if the energy of excited pulses is rise and their sequence period is decreased. The DF depletion disappears if time interval between pulses in the series is > 5 s. This phenomenon is due two process competition: fast consumption of singlet oxygen by oxidation of cell organelles right after laser pulse excitation and slow diffusive recovery of oxygen concentration in the pause between the pulses. Statistically valid distinction between DF characterization as well as LQDF erythrosine extent in healthy and pathological tissues was established. The use of this phenomenon will greatly simplify the determination of radiation “dose” in photodynamic therapy (PDT) directly during the treatment session.

 

Didenko, N.V., Konyashchenko, A.V., Kostryukov, P.V., Losev, L.L., Pazyuk, V.S., Tenyakov, S.Y., Bryukhanov, V.V.

Temporal compression of pulses from a 100-kHz-repetiton-rate femtosecond ytterbium laser

(2016) Quantum Electronics, 46 (8), pp. 675-678.

DOI: 10.1070/QEL16147

КРАТКОЕ ОПИСАНИЕ: We report the temporal compression a femtosecond ytterbium laser pulse at a pulse repetition rate of 100 kHz using the effect of nonlinear self-phase modulation in a gas-filled capillary. A 260-fs laser pulse is compressed down to 17 fs with an energy efficiency of 40%. An average radiation power at the compressor output is 2 W. At a second compression stage, the time contrast is increased and the pulse duration is reduced in the process of the second harmonic generation in a KDP crystal. The obtained pulses have a duration of 11 fs at an efficiency of 35%.

 

Bryukhanov, V.V., Konstantinova, E.I., Borkunov, R.Yu., Tsarkov, M.V., Slezhkin, V.A.

Influence of silver nanoparticles on relaxation processes and efficiency of dipole - Dipole energy transfer between dye molecules in polymethylmethacrylate films

(2015) Quantum Electronics, 45 (10), pp. 908-913.

DOI: 10.1070/QE2015v045n10ABEH015791

КРАТКОЕ ОПИСАНИЕ: The fluorescence and phosphorescence of dyes in thin polymethylmethacrylate (PMMA) films in the presence of ablated silver nanoparticles has been investigated in a wide temperature range by methods of femtosecond and picosecond laser photoexcitation. The fluorescence and phosphorescence times, as well as spectral and kinetic characteristics of rhodamine 6G (R6G) molecules in PMMA films are measured in a temperature range of 80 - 330 K. The temperature quenching activation energy of the fluorescence of R6G molecules in the presence of ablated silver nanoparticles is found. The vibrational relaxation rate of R6G in PMMA films is estimated, the efficiency of the dipole - dipole electron energy transfer between R6G and brilliant green molecules (enhanced by plasmonic interaction with ablated silver nanoparticles) is analysed, and the constants of this energy transfer are determined.

 

Bryukhanov, V.V., Minaev, B.M., Tsibul’nikova, A.V., Slezhkin, V.A.

The effect of gold nanoparticles on exchange processes in collision complexes of triplet and singlet oxygen molecules with excited eosin molecules

(2015) Optics and Spectroscopy (English translation of Optika i Spektroskopiya), 119 (1), pp. 29-38.

DOI: 10.1134/S0030400X15070061

КРАТКОЕ ОПИСАНИЕ: We have studied exchange processes in contact complexes of triplet eosin molecules with oxygen molecules in the triplet (3Σg−) and singlet (1Δg) states in thin polyvinylbutyral films in the presence of gold nanoparticles. Upon resonant excitation of surface plasmons in gold nanoparticles into the absorption band of eosin molecules-singlet oxygen sensitizers-we have obtained an increase in the intensity of the delayed fluorescence and an increase in the lifetime of the dye with simultaneous quenching of the luminescence of singlet oxygen. The kinetics of the delayed fluorescence of the dye as a result of singlet-triplet annihilation of triplet eosin molecules with singlet oxygen molecules has been investigated. To compare theoretical and experimental data, we have numerically simulated energy transfer processes. Rate constants of energy transfer and of singlet-triplet annihilation, as well as quenching constants of triplet states of the dye by molecular oxygen, have been calculated. Luminescence quantum yield 1Δg of polyvinylbutyral has been estimated. We have analyzed quantum-chemically electronic mechanisms of singlet-triplet annihilation of oxygen and eosin.

 

Tsibul’nikova, A.V., Bryukhanov, V.V., Slezhkin, V.A.

Enhancement of singlet-triplet energy transfer between dyes in a polymer film by surface plasmons of gold nanoparticles

(2015) Russian Physics Journal, 57 (12), pp. 1716-1724.

DOI: 10.1007/s11182-015-0443-7

КРАТКОЕ ОПИСАНИЕ: The effect of the plasmon energy generated in Ag citrate hydrosol and ablated Au nanoparticles on the singlet- triplet electron energy transfer between rhodamine 6G (R6G) and acriflavine (ACF) molecules incorporated into polyvinyl alcohol (PVA) films is studied. The increased efficiency of non-radiative energy transfer in the presence of Au nanoparticles and the increased lifetime of excited states of molecules are established.

 

Khalyapin, V.A.

Longitudinal-transverse dynamics of super-Gaussian pulses in isotropic dielectrics

(2015) Optics and Spectroscopy, 119 (1), pp. 135-138.

DOI: 10.1134/S0030400X15070140

КРАТКОЕ ОПИСАНИЕ: The set of equations governing the dynamics of the parameters of a super-Gaussian pulse propagating in an isotropic dielectric in regions of both normal and anomalous group velocity dispersion is obtained. It is demonstrated that stimulated Raman scattering can suppress the formation of a nonlinear focus. The expression for critical power of the signal for which self-focusing can still be compensated by diffraction-limited divergence is derived.

 

Bryukhanov, V.V., Minaev, B.F., Tsibul'nikova, A.V., Tikhomirova, N.S., Slezhkin, V.A.

Plasmon amplification and quenching of the fluorescence and phosphorescence of anionic and cationic dyes in various media

(2014) Journal of Optical Technology, 81 (11), pp. 625-630.

DOI: 10.1364/JOT.81.000625

КРАТКОЕ ОПИСАНИЕ: This paper discusses how the nanoparticles of a silver citrate hydrosol affect the fluorescence and phosphorescence intensity and lifetime of anionic and cationic dye molecules. It is found that, depending on the nanoparticle concentration of the silver hydrosol, there is both amplification and quenching of the fluorescence and phosphorescence of the molecules. Interaction mechanisms are observed between excitation by the molecules and by the silver nanoparticles.

 

Bryukhanov, V.V., Tsibul’nikova, A.V., Samusev, I.G., Slezhkin, V.A.

Effect of Silver Nanoparticles on Singlet–Singlet Energy Transfer Dynamics of Luminophores in Thin Films of Polyvinyl Alcohol

(2014) Journal of Applied Spectroscopy, 81 (4), pp. 570-576.

DOI: 10.1007/s10812-014-9971-0

КРАТКОЕ ОПИСАНИЕ: The effect of silver ablated nanoparticles (ANP) on the non-radiative inductance–resonance energy transfer dynamics and the phosphorescence in a donor–acceptor pair of eosin and methylene blue (MB) luminophores embedded in polyvinyl alcohol thin films with silver ANP was investigated. The fluorescence intensity of the donor (eosin) and acceptor (MB) and the dipole–dipole transfer efficiency increased with resonant excitation of silver ANP surface plasmons in the donor absorption band. Luminescence quantum yields and fluorescence lifetimes were measured. Energy-transfer constants, the degree of polarization, and the fluorescence anisotropy were determined.

 

Myslitskaya, N.A., Samusev, I.G., Bryukhanov, V.V.

Dipole-Dipole Electron Excitation Energy Transfer in the System CdSe/ZnS Quantum Dot – Eosin in Butyral Resin Matrix

(2014) Russian Physics Journal, 57 (7), pp. 920-928.

DOI: 10.1007/s11182-014-0325-4

КРАТКОЕ ОПИСАНИЕ: The electron excitation energy transfer from CdSe/ZnS quantum dots to eosin molecules in the polymer matrix of butyral resin is investigated. The main characteristics of energy transfer are determined. By means of luminescence microscopy and correlation spectroscopy methods we found that quantum dots in the polymer are in an aggregate state.

 

Khalyapin, V.A.

Transverse longitudinal dynamics of the super-Gaussian pulses of a modified nonlinear Schrodinger equation

(2014) Bulletin of the Russian Academy of Sciences: Physics, 78 (12), pp. 1320-1323.

DOI: 10.3103/S1062873814120119

КРАТКОЕ ОПИСАНИЕ: A system of equations is obtained that describe the dynamic parameters of super-Gaussian pulses propagating in an isotopic dielectric. It is shown that a nonlinearity dispersion can suppress the formation of the nonlinear focus. An expression is derived for the critical signal power at which self-focusing can still be compensated for by diffraction divergence.

 

Myslitskaya, N.A., Khitrin, A.V., Ivanov, A.M., Samusev, I.G., Bryukhanov, V.V.

Dynamics of colloid silver nanoparticles in an evaporating water drop

(2012) Russian Physics Journal, 54 (11), pp. 1280-1285.

DOI: 10.1007/s11182-012-9743-3

КРАТКОЕ ОПИСАНИЕ: The method of photon correlation spectroscopy is used to investigate the distribution of the diffusion coefficient of silver nanoparticles in an evaporating water drop given that the drop base area remains unchanged (the pinning condition). It is established that the capillary flow dominates over the diffusion nanoparticle motion in redistribution of concentration of the dissolved nanoparticles.


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